Further Studies on the Interaction Between Prostaglandins and Syntocinon on the Isolated Pregnant Human Myometrium

Summary Interaction between prostaglandins and Syntocinon is shown to be of two kinds. There may be potentiation, where an increased response to Syntocinon follows combination with a low dose of prostaglandin, and enhancement, which is of much longer duration. Potentiation can be produced by both E and F prostaglandins, whereas enhancement is confined to E prostaglandins. Varying the doses of prostaglandin E is shown to have little effect on the degree of enhancement produced. The physiological implications and clinical applications of these interactions are discussed.