Why the study?
Does ischemic preconditioning prevent reperfusion arrhythmias and local renin release in ex vivo guinea pig hearts and cultured mast cells?
Population
Guinea pig hearts ex vivo and cultured mast cells (HMC-1)
Comparison
Ischemic preconditioning and pharmacological… vs Ischemia/reperfusion without preconditioning
Design
Preclinical
Authors
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Hypothesis-generating for mast cell ALDH2 in reperfusion arrhythmias; should not change clinical practice.
Does ischemic preconditioning prevent reperfusion arrhythmias and local renin release in ex vivo guinea pig hearts and cultured mast cells?
Ischemic preconditioning protects against reperfusion arrhythmias by preventing renin release from cardiac mast cells via an A2b/A3 receptor, PKCepsilon, and ALDH2 signaling cascade.
Koda et al. (2010) studied this question.
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