The similar serum phosphate concentrations found in our patient and in the control subjects by this method suggest that little if any excess phosphate was present; we confirmed this with binding studies using phos- phorus-32 (data not shown).These findings suggest that a paraprotein interfered in an undetermined way with the chromogenic assay and the apparent high serum phosphate concentration can be described as pseudohyperphosphataemia.As many patients with myeloma have concurrent renal impairment3 cautious interpretation of apparent hyperphosphataemia is required before specific treatment is given.
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Craddock et al. (1989) studied this question.
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