Gonadotropin‐releasing hormone (GnRH) stimulates luteinizing hormone (LH) and follicle‐stimulating hormone (FSH) release from pituitary gonadotrope cells. Additional receptor‐mediated actions of the releasing hormone include homologous regulation of both the GnRH receptor and of cell responsiveness. While it is apparent that the release mechanism is Ca 2+ mediated, it remains unclear how this receptor‐mediated action is integrated with regulation of the receptor and with cell responsiveness. It is the purpose of this review to describe the requirements for gonadotropin release as well as for receptor and response regulation in order to prepare an integrated model for these actions of the releasing hormone.
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Conn et al. (1985) studied this question.
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