Hypogonadotropic Hypogonadism Associated with Anosmia in the Female

THE syndrome of hypogonadotropic hypogonadism associated with anosmia rarely occurs in females.1 2 3 4 5 Gonadotropin levels and indexes of estrogen production in three affected females were studied, and the clinical response to clomiphene citrate and to exogenous gonadotropins was assessed. Although indirect evidence of the induction of ovulation with exogenous gonadotropins in a similar case was presented by Mroueh and Kase,1 there have been no previous reports on females with this disorder in whom the induction of ovulation was proved by pregnancy or by visualization of corpora lutea. In the two married patients described below, the induction of ovulation resulted in normal . . .