Population
Human cardiac hKv1.5 channel model
Comparison
Quinine, clofilium, and tetrapentylammonium (TPeA) vs Quinidine and control conditions
Design
Preclinical
Authors
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These affinities may guide Kv1.5 blocker design; leaves open translation to in vivo antiarrhythmic efficacy.
The affinity and kinetics of antiarrhythmic drugs acting as cationic open-channel blockers on hKv1.5 channels are largely determined by the intrinsic stability of the drug-receptor complex, likely involving hydrophobic interactions.
Snyders et al. (1995) studied this question.
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