Cell Kinetics and Practical Consequences for Therapy of Acute Leukemia

KNOWLEDGE of the patterns of cell kinetics in acute leukemia has increased remarkably during the past two decades. Previously, the selective advantage of the malignant-cell population was attributed to rapid and uncontrolled proliferation, and chemotherapeutic strategies were thus designed primarily to interfere with cell division. Today, it is recognized that cell division is not more rapid in the malignant population than in normal cell counterparts. Furthermore, there is good evidence that the growth of malignant cells is influenced by regulatory mechanisms, which principally affect the proportion of tumor cells in an active phase of cycle.This presentation describes current understanding . . .