Pulmonary blood flow significantly increases in patients with transposition of the great arteries and intact ventricular septum after 2 months of age.
Pulmonary flow rises after 2 months in TGA/IVS; hypothesis-generating and requires prospective validation before guiding intervention timing.
Pulmonary blood flow and left ventricular volumes were determined angiographically from 33 studies on 30 patients (2I male, 9 female) with transposition of the great arteries and intact ventricular septum. Twelve of the studies were performed on infants under 2 months of age (median age 33 hours). The pulmonary blood flow in this group ranged from I 3 to 4 8 (mean, 3 0) 1./min/m2. There were 21 studies on patients over 2 months of age (median age I6 months) with a pulmonary blood flow ranging from 3 9 to II -3 (mean = 6 4) l./min/m2. This difference in mean pulmonary bloodflow was statistically significant (P< o-ooi).
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Keane et al. (1973) studied this question.
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