Electron paramagnetic resonance is a useful high-resolution tool for studying the structural and dynamic properties of muscle proteins such as myosin and Ca-ATPase.
EPR-spin labeling enables high-resolution myosin and Ca-ATPase analysis; leaves open clinical translation without prospective validation.
Electron paramagnetic resonance: a high-resolution tool for muscle physiology. Exerc. Sport Sci. Rev., Vol. 29, No. 1, pp 3-6, 2001. Skeletal muscle function can be altered by changes in protein structure and motion. Electron paramagnetic resonance (EPR) paired with site-directed spin labeling has been used to study the relationships between (a) muscle force and myosin structure and (b) muscle relaxation and Ca-ATPase motion and structure.
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Thompson et al. (2001) studied this question.
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