17-α-hydroxyprogesterone-17-n-caproate (HPC) is an active progestational compound possessing prolonged activity, in confirmation of Junkmann(3). 2. Modification of the oily vehicle has resulted in an earlier peak response to HPC in virgin female rabbits, without affecting duration of action. 3. It has been verified that 17-α-hydroxyprogesterone is an extremely weak progestational agent.
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Kessler et al. (1957) studied this question.