Changes in some of the specific mechanisms which transport cations across cell membranes have been demonstrated in patients suffering from affective illness. A number of novel strategies have been evaluated in the management of both mania and depression, based on the following observations: (1) State‐related changes in cation transport; (2) The effects of established psychotherapeutic drugs upon cation transport; and (3) theories regarding control of membrane ion flux. This article reviews the background to these novel strategies and evaluates the possible significance of changes in a number of different cation transport systems to the treatment of the affective disorders.
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A. J. Wood (1987) studied this question.
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