Synthesis and characterization of biobased isosorbide-containing copolyesters as shape memory polymers for biomedical applications

H NMR, FTIR, DSC, and WAXD. The chain composition, melting point and crystallinity of the PBISI copolyesters can be tuned continuously by changing the content of isosorbide. The crosslinked copolyester is demonstrated to be a promising shape memory polymer (SMP) with excellent shape memory properties including shape fixity and shape recovery rate close to 100%. The switching temperatures of PBISI-based SMPs can be tuned between 26 °C and 54 °C by altering the composition of PBISI copolyesters and curing extent. Cell adhesion and proliferation were adopted to evaluate the potential biocompatibility of PBISI-based SMPs, and the results indicated that all the PBISI-based SMPs were essentially noncytotoxic, making them suitable for fabricating biomedical devices.