Why the study?
Accelerated systemic vascular calcification involving intimal atherosclerosis and medial calcific sclerosis in end-stage renal disease creates unique challenges for coronary revascularisation.
Highlights the utility of intravascular lithotripsy-assisted PCI and pacemaker implantation in managing complex calcific coronary disease and concomitant arrhythmias in end-stage renal disease.
Patients with end-stage renal disease experience an accelerated form of systemic vascular calcification involving both intimal atherosclerosis and medial calcific sclerosis (Mönckeberg's sclerosis). This dual pathology creates unique challenges for coronary revascularisation. We present a dialysis-dependent woman with severe calcific critical left main stem bifurcation disease who underwent successful intravascular lithotripsy-assisted, optical coherence tomography-guided percutaneous coronary angioplasty. She had concomitant severe bradycardia from sinoatrial node dysfunction with paroxysmal atrial fibrillation, which resolved with implantation of a pacemaker. This case highlights the pathobiology underpinning dysmorphic vascular calcification in end-stage renal disease, its impact upon the complex cardiac presentation, and the need for a specialised device-based strategy to achieve a favourable outcome.
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Ng et al. (2025) studied this question.
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