Intracellular Regeneration of Glucocorticoids by11β-Hydroxysteroid Dehydrogenase (11β-HSD)-1 Plays a KeyRole in Regulation of the Hypothalamic-Pituitary-Adrenal Axis: Analysisof 11β-HSD-1-Deficient Mice**The Wellcome Trust supported this work through a program grant (to J.J.M. and J.R.S.) and a Career Development Fellowship (to M.C.H.).