Fluorous Biphasic Catalysis without Perfluorinated Solvents: Application to Pd-Mediated Suzuki and Sonogashira Couplings

With and now without: Perfluoro-tagged catalysts immobilized on fluorous reversed-phase silica gel can be used for Suzuki and Sonogashira C–C coupling reactions (see scheme; R1=e.g., phenyl, 4-MeOC6H4, R2=e.g., 4-NO2C6H4, 4-MeCOC6H4, X=Br, I) without the need for perfluorinated solvents. After the reaction the products were isolated by decantation and the Pd catalysts were recovered and reused.