system of the ovarian secretion, it is at present impossible -to determine.I believe, with Dr. Ernest Young, that only by careful -clinical notes of these cases carried over several years, together with skiagrams of the joints taken from time to -time, shall we be in a position to say definitely that the -condition we call osteo-arthritis is simply a degenerative process, which may follow in any joint where there has been chronic irritation, be it gouty, infective, rheumatoid, *or due to trauma.-Iam, etc.,
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Geo. H. Peake (1911) studied this question.