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The metabolism in vitro of p-methoxyamphetamine by liver preparations of rabbit, guinea-pig and rat was investigated.2. Four metabolic products, N-hydroxy-p-methoxyamphetamine, 1-(p-methoxyphenyl)-propan-2-one oxime, 1-(p-methoxyphenyl)-propan-2-one and 1-(p-methoxyphenyl)-propan-2-ol were isolated and identified by comparing physical properties with those of authentic compounds.3. The properties and assay procedures for the examination of the labile N-hydroxy-p-methoxyamphetamine were investigated.
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Beckett et al. (1974) studied this question.
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