Interesting Reactions Incidental to the Treatment of Two Cases of Bronchial Asthma

It is now well known that naturally sensitive individuals give a skin test to the proteins to which they are sensitive and thus presumably have many antibodies fixed in the cells of their skin. In connection with other work done in New York in 1915-1916, Dr. Longcope and I attempted to demonstrate circulating antibodies either as precipitins or as so-called anaphylactins in the blood serum of these naturally sensitive individuals, but always with a negative result. Cooke¹could find no circulating antibodies in the blood of hay-fever patients. Schloss²and also Koessler³succeeded in finding circulating antibodies in a case of egg susceptibility and hay-fever, respectively, and recently Walker⁴has reported the irregular appearance of complement fixing antibodies and precipitins in patients naturally sensitive to horse hair and cat hair proteins. In view of the fact that, in the case of artificial sensitization, circulating antibodies appear