The test on the configurational stability of chiral organolithium compounds is based on the kinetic resolution of the racemic organolithium compound on reaction with an enantiomerically pure electrophile. The limits of this test have been evaluated by model calculations. The factors that have been considered are: Optimum values for the kinetic resolution; effects of < 100% enantiomeric purity of the chiral electrophile; parallel side reactions of the organolithium compounds with the electrophile.
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Hirsch et al. (1992) studied this question.
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