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The tie that binds: Rotaviruses bind to their host cells through the interaction of the virion outer capsid and spike proteins with receptors including sialic acid containing glycoconjugates. Intact rotavirus particles interact with the glycan of the GM3 ganglioside (see picture) primarily through the N-acetylneuraminic acid, but the penultimate galactose residue also contributes.
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Haselhorst et al. (2011) studied this question.
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