Why the study?
Epicardial adipose tissue directly covers the atrial myocardium, and its role in triggering and maintaining atrial fibrillation through mechanisms such as inflammation, fibrosis, infiltration, autonomic dysfunction, and oxidative stress requires review.
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Design
Review
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This review highlights the pathophysiological mechanisms by which epicardial adipose tissue contributes to the development and maintenance of atrial fibrillation.
Atrial fibrillation is the most common arrhythmia leading to cardiogenic stroke. Without membranous sructure between epicardial adipose tissue and atrial myocardium, epicardial adipose tissue directly covers the surface of the atrial myocardium. The formation of an epicardial adipose tissue inflammatory microenvironment, fibrosis, infiltration by epicardial adipose tissue, autonomic dysfunction and oxidative stress are important mechanisms that trigger and maintain atrial fibrillation. Those mechanisms are reviewed herein.
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Wang et al. (2022) studied this question.
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