Why the study?
Because atherogenic LDL and protective adiponectin bind to T-cadherin, researchers investigated whether the ratio of circulating LDL to HMW adiponectin could predict the development of atherosclerosis.
Do circulating T-cadherin levels, HMW adiponectin, and T-cadherin gene SNPs predict carotid atherosclerosis in blood donors?
Do circulating T-cadherin levels, HMW adiponectin, and T-cadherin gene SNPs predict carotid atherosclerosis in blood donors?
The G allele of the rs12444338 SNP in the T-cadherin gene and circulating T-cadherin levels correlate with thinner carotid IMT, suggesting a potential atheroprotective marker.
T-cadherin SNP and levels associated with thinner IMT in males; hypothesis-generating and should not yet inform clinical atherosclerosis risk assessment.
In the cardiovascular system, atherogenic low-density lipoproteins (LDL) and the protective hormone adiponectin bind to the same receptor, T-cadherin. In this study, we tested the hypothesis that the ratio of circulating LDL to high-molecular weight (HMW) adiponectin could predict the development of atherosclerosis. Using enzyme-linked immunosorbent assay, we measured the level of circulating HMW adiponectin in the blood of donors together with ultrasound measuring of intima-media thickness (IMT) of carotid arteries. Single-nucleotide polymorphisms in the T-cadherin gene were identified using polymerase chain reaction. We found that carotid artery IMT is inversely correlated with the level of HMW in male subjects. We also found that the G allele of rs12444338 SNP in the T-cadherin gene correlates with a lower level of circulating T-cadherin and thinner IMT and therefore could be considered as an atheroprotective genotype. Despite our data, we could not provide direct evidence for the initial study hypothesis. However, we did uncover an important correlation between circulating T-cadherin and thinner carotid IMT.
No takes yet. Share an insight, caveat, or question.
Balatskiy et al. (2021) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: