Botulinum neurotoxin A (BoNT/A) has become a valuable tool in the treatment of neurological disorders associated with increased muscle tone and has revolutionized the treatment of dystonia and focal spasticity. It acts at cholinergic nerve terminals by cleaving SNAP-25, a protein involved in the fusion of synaptic vesicles with the presynaptic membrane. 1 Cholinergic autonomic parasympathetic and postganglionic sympathetic nerve synapses are also amenable to treatment with botulinum toxin. Within the last few years, an increasing number of articles have been published focusing on new applications for BoNT/A. This short review gives an overview on recent indications of BoNT/A in the treatment of disorders of the autonomic nervous system and an outlook on possible future application.
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Jost et al. (1999) studied this question.
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