Chronic hyperglycemia was produced in 90-95% of adult white rats which had been starved for 48-60 hours and then injected subcutaneously with 175 mg of alloxan per kg. Only 25% of rats which had not been starved became hyperglycemic after injection of a similar dose. The hyperglycemia is persistent and relatively benign; few spontaneous recoveries or fatalities occurred within 3-4 months after injection of alloxan.
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Kass et al. (1945) studied this question.