The formation of cartilage-like aggregates in high-density stationary cultures of trypsinized chick embryo precartilage cells is blocked by low concentrations of hyaluronate. Thyroxine (and triiodothyronine), growth hormone, calcitonin, and adenosine 3',5'-monophosphate prevented this inhibition by hyaluronate, whereas other hormones tested did not.
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Bryan P. Toole (1973) studied this question.
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