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The RanGTPase system has multiple functions in both interphase and mitosis. Extensive studies of Ran-driven nucleocytoplasmic transport have contributed significantly toward our understanding of how RanGTP is produced, hydrolyzed, and localized in interphase. However, there is still a lack of understanding about how this system operates in mitosis. Recent advances have begun to shed light on how RanGTP is produced and localized in mitotic mammalian cells.
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Li et al. (2004) studied this question.
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