Remarkable stability is shown by the recently observed 3H isomer 1 of indole (2) (τ ≅ 100 s at pH ≅ 9 and 25°C). The equilibrium constant pKT of the tautomerization of 2 to 1 is 5.8 ± 0.2; in other words, the equilibrium concentration of 1 lies in the range of 1 to 2 ppm. The tautomerization is catalyzed by acid and—less efficiently—by base.
No takes yet. Share an insight, caveat, or question.
Gut et al. (1994) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: