An enzyme is described which catalyses the transfer of the methyl group of S‐adenosylmethionine to histamine at the imidazole nitrogen remote from the side chain. A method for the assay of the enzymic activity is described. The enzymic activity is enhanced with increasing pH. The influence of certain inhibitors examined suggests that the enzyme has essential sulfhydryl groups. Studies on the intracellular distribution indicate that the enzyme is localized to the soluble cytoplasm. The enzyme has been found in the liver of mouse, pig, hamster, rabbit, cat, and man.
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Kerstin M. Lindahl (1960) studied this question.
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