Saturated seven-membered rings containing an O atom—oxepanes— are found increasingly in nature. A new, highly promising strategy for the synthesis of oxepanes 3 starts from the dithionoesters 1, which, upon irradiation, cyclize with loss of S2 to give the olefins 2. Regioselective hydrolysis with tautomerization leads finally to the oxepanes 3.
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Nicolaou et al. (1988) studied this question.
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