The Effect of Portacaval Shunt on Thrombocytopenia Associated with Portal Hypertension

Article1 October 1961The Effect of Portacaval Shunt on Thrombocytopenia Associated with Portal HypertensionBENJAMIN H. SULLIVAN JR., M.D., F.A.C.P., HENRY J. TUMEN, M.D., F.A.C.P.BENJAMIN H. SULLIVAN JR., M.D., F.A.C.P.Search for more papers by this author, HENRY J. TUMEN, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-55-4-598 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe association of chronic liver disease, splenomegaly, and hematologic disturbances has been known for many years. Banti's classic description in 1894 (1) has been followed by other studies demonstrating the role of portal hypertension in the production of abnormal hematologic states (2, 3). Dameshek and Estren (4) developed the concept of hypersplenism, a syndrome characterized by splenomegaly, anemia, leukopenia, thrombocytopenia, and bone marrow hyperplasia. Liver disease and portal hypertension are important causes of the disorder and splenectomy is curative. Moschowitz (5) described the morphologic features of "congestive splenomegaly" as seen in 86 patients, including 39 cirrhotics and 23 with other...References1. BANTI G: La splenomegalia con cirrose del fegato. Sperimentale 48: 407, 1894. Google Scholar2. LARRABEE RC: Chronic congestive splenomegaly and its relationship to Banti's disease. Amer. J. Med. Sci. 188: 745, 1934. CrossrefGoogle Scholar3. WHIPPLE AO: Problem of portal hypertension in relation to hepatosplenopathies. Ann. Surg. 122: 449, 1945. CrossrefMedlineGoogle Scholar4. DAMESHEKESTREN WS: The Spleen and Hypersplenism, Grune and Stratton, New York, 1947. Google Scholar5. MOSCHCOWITZ E: The pathogenesis of splenomegaly in hypertension of the portal circulation; "congestive splenomegaly." Medicine 27: 187, 1948. CrossrefMedlineGoogle Scholar6. SHEEHYBERMAN TWA: The anemia of cirrhosis. J. Lab. Clin. Med. 56: 72, 1960. MedlineGoogle Scholar7. CUSTER RP: The so-called hypersplenic syndrome: its pathogenesis, recognition and management. Trans. Coll. Physicians Phila. 26: 1, 1958. MedlineGoogle Scholar8. MACPHERSONINNES AIJ: Peripheral blood picture after operation for portal hypertension. Lancet 2: 1120, 1953. CrossrefGoogle Scholar9. MACPHERSON AI: Surgical treatment of portal hypertension. Lancet 1: 353, 1956. CrossrefGoogle Scholar10. MACPHERSON AI: Assessment of the results of surgical treatment in portal hypertension. Gastroenterology 38: 142, 1960. CrossrefMedlineGoogle Scholar11. WELCHRAMOS CSAG: Results of portacaval shunts in the treatment of portal hypertension. Surgery 41: 756, 1957. MedlineGoogle Scholar12. FERGUSON DJ: Experience with surgery for portal hypertension. J. Lancet 77: 426, 1957. MedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Philadelphia, PennsylvaniaReceived for publication June 5, 1961.From Walter Reed General Hospital, Washington, D. C., and the Department of Medicine, Graduate School of Medicine, University of Pennsylvania, Philadelphia, Pa.Requests for reprints should be addressed to Benjamin H. Sullivan, Jr., M.D., 1830 Rittenhouse Square, Philadelphia 3, Pa. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByIncidence, Prevalence, and Clinical Significance of Abnormal Hematologic Indices in Compensated CirrhosisLiver Fibrosis Is Associated with Decreased Peripheral Platelet Count in Patients with Chronic Hepatitis B and CHemostatic Defects in End Stage Liver DiseaseEffect of transjugular intrahepatic portosystemic shunt on secondary hypersplenismPlatelet autoantibodies in patients with chronic liver diseaseCourse of thrombocytopenia of chronic liver disease after transjugular intrahepatic portosystemic shunts (TIPS)Sonographic Demonstration of Reversible Portal Vein Thrombosis Following Splenectomy in an AdolescentEffect of operations for variceal hemorrhage on hypersplenismPlatelet-Associated IgG in Acute and Chronic Hepatic DiseasesEffect of portacaval anastomosis on hypersplenismHYPERSPLENISM AND PORTAL HYPERTENSIONBIBLIOGRAPHYHemostatic Mechanisms in Liver Disease*Indikationen zur Splenektomie bei BlutkrankheitenCoagulation defects in patients with cirrhosis of the liver undergoing portasystemic shuntsIron Kinetics in Laennec’s CirrhosisLiver Disease 1 October 1961Volume 55, Issue 4Page: 598-603KeywordsAnemiaCirrhosisGraduate medical educationHemorrhageHospital medicineHypertensionLiver diseasesPortal hypertensionSplenectomySplenomegaly Issue Published: 1 October 1961 PDF DownloadLoading ...