Hyperapobetalipoproteinemia. Plasma lipoprotein responses to oral fat load.
Why the study?
Does an oral fat load alter lipid transport and lipoprotein subfractions differently in patients with hyperapobetalipoproteinemia compared to normolipidemic controls?
Population
19 patients total: 6 normotriglyceridemic patients with hyperapobetalipoproteinemia, 6 normolipidemic…
Comparison
Oral fat load vs Normolipidemic controls
Design
Case-control
Follow-up
7 hours
Authors
Discussion
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Implication
Abnormal postprandial lipemia in hyperapoB may heighten atherogenic risk; leaves open whether targeting these responses improves outcomes.
Structured PICO
Does an oral fat load alter lipid transport and lipoprotein subfractions differently in patients with hyperapobetalipoproteinemia compared to normolipidemic controls?
P
Population
19 patients total: 6 normotriglyceridemic patients with hyperapobetalipoproteinemia (HyperapoB), 6 normolipidemic controls, and 7 patients with Type IV hyperlipoproteinemia (3 with normal LDL apo B, 4 with HyperapoB).
I
Intervention
Oral fat load
C
Comparator
Normolipidemic controls
O
Outcome
Changes in plasma triglycerides, Sf > 400 and Sf 20-400 triglycerides, Sf > 20 B100, total HDL, and HDL subfractions (HDL2 and HDL3) over a 7-hour periodsurrogate
Patients with hyperapobetalipoproteinemia demonstrate abnormal postprandial lipid metabolism characterized by prolonged triglyceride elevation and decreased HDL2 cholesterol following fat ingestion.
Cite This Study
Genest et al. (1986) studied this question.