Why the study?
Loss-of-function mutations in LPL or GPIHBP1 cause severe hypertriglyceridemia, but structures for LPL and GPIHBP1 have remained elusive.
Population
Crystallized LPL–GPIHBP1 complex
Design
Crystallization and structural analysis
Authors
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May guide mutation effects in hypertriglyceridemia; leaves open human translation from animal models.
The structural elucidation of the LPL-GPIHBP1 complex provides a mechanistic basis for how GPIHBP1 stabilizes LPL and offers insights into loss-of-function mutations causing severe hypertriglyceridemia.
Birrane et al. (2018) studied this question.
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