A range of pulses commonly used for human transcranial ultrasound stimulation are clearly audible

Transcrianial focused ultrasound (TUS) has great potential for use as a non-invasive focal brain stimulation technique. It has been proposed that TUS directly modulates neuronal function and firing [1,2], though the exact mechanism is currently not well understood. Recently, the presence of an auditory confound has been noted when applying TUS in both animal models and humans [3,4]. This prevents participant blinding and causes activation of auditory cortices, confounding the interpretation of electrophysiological or behavioural changes seen with TUS [5–7].