The chiral diphosphinite H8‐BINAPO derived from H8‐BINOL has been used in the Ir‐catalyzed asymmetric hydrogenation of quinolines, and high enantioselectivity (up to 97% ee) was obtained. Immobilization of the iridium catalyst in poly(ethylene glycol) dimethyl ether (DMPEG) is also discussed. With DMPEG/hexane biphasic system, better enantioselectivities were obtained as compared to those observed in aprotic organic solvents.
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Lam et al. (2005) studied this question.
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