A series of compounds possessing a ‘Steroid‐type’ scent and related to 4‐(4′‐ t ‐butylcyclohexyl)‐4‐methyl‐2‐pentanones ( 1 and 2 ) has been synthesized. The odor of these compounds has been found to be dependent on their conformation; only when the molecule can assume a steroid‐like shape there is an interaction with the odor chemoreceptor.
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Ohloff et al. (1983) studied this question.
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