Characterization of potassium currents modulated by BRL 38227 in rat portal vein

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Population

Smooth muscle cells dispersed from rat portal vein

Design

Preclinical

Authors

Discussion

Provides mechanistic insight into K+ channel modulation in vascular smooth muscle; leaves open translation to human therapeutics.

Population

Smooth muscle cells dispersed from rat portal vein

Intervention

BRL 38227 (0.1 to 10 microM)

Outcome

Membrane potassium currents (IKCO, I(TO)) and membrane potentialsurrogate

BRL 38227 modulates potassium currents in rat portal vein smooth muscle cells, acting as a potassium channel opener.

Noack et al. (1992) studied this question.

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