Answers are grounded in this paper and cite their sources.
The cross-coupling of 3-iodo- and 3-bromopyridine with the carbanions derived from ethyl cyanoacetate and malononitrile in the presence of tetrakis(triphenylphosphine)palladium in 1, 2-dimethoxyethane gave ethyl α-cyanopyridine-3-acetate and 3-pyridinemalononitrile in moderate yields. This palladium-catalyzed cross-coupling proceeded smoothly with halopyrimidines, haloquinolines, haloisoquinolines, and also bromobenzene.
No takes yet. Share an insight, caveat, or question.
Sakamoto et al. (1988) studied this question.
Synapse has enriched 10 related papers. Consider them for comparative context: