The influence of Bioglass (BG) on the growth of L cells was studied by means of tissue culture, to get an idea on its bone-bonding mechanism. Growth rate of L cells on BG was lower than that on the control silica glass (SG). L cells on BG diminished in size and took up long and slender polygonal shapes with radially spread long pseudopods, which probably meant that the cell cycle was detained at the synthetic period. From these findings, BG is thought to have an inhibitory effect on the growth of L cells, which might arrest the fibrous tissue encapsulation and allow bonding with bone.
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Matsuda et al. (1987) studied this question.
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