The acceptance of the central position occupied by pyruvic acid in the intermediary metabolism of carbohydrate in animal tissues has recently led to a number of investiga- tions on the behaviour of other oc-keto-acids towards those enzymes which act upon pyruvic acid. The next higher homologues of pyruvic acid, namely, ao-ketobutyric and oc-ketovaleric acids, have received special attention [Green, Needham & Dewan, 1937; McGowan & Peters, 1937; Long & Peters, 1939; Cohen, 1939].
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Cyril Long (1942) studied this question.
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