Key result
Patient self-testing of INR at home demonstrated noninferior warfarin stability compared with routine methods, achieving 69.2% vs 64.3% of tests within the therapeutic range (P=0.07).
Why the study?
Does patient self-testing of INR at home improve time in therapeutic range compared to routine hospital testing in pediatric patients on long-term warfarin?
Cohort (n=164)
No
Does patient self-testing of INR at home improve time in therapeutic range compared to routine hospital testing in pediatric patients on long-term warfarin?
Absolute Event Rate: 69.2% vs 64.3%
p-value: p=0.07
Patient self-testing of INR at home demonstrates noninferior warfarin stability compared to routine hospital testing in pediatric patients.
May support home INR self-testing in pediatric warfarin patients; hypothesis-generating and requires randomized confirmation before practice change.
The complexity of managing children with chronic disease has led to an increase in the use of long-term warfarin therapy. Time in therapeutic range (TTR) is the preferred method for determining efficacy and stability of warfarin management. This study aimed to determine the TTR achievement and incidence of adverse events among pediatric warfarin patients managed by an anticoagulation clinic over 12 months and to compare TTR achievement between patients self-testing (PST) at home and those monitored using routine methods. International normalized ratio (INR) results reported for 2012 for children currently having their warfarin therapy managed by a dedicated pediatric anticoagulation clinic were analyzed. Warfarin-related adverse events were recorded. A total of 164 patients were included. In total, 93 children performed PST and 71 children tested their INR at a hospital or pathology service. TTR achievement for the cohort was 67.1% (95% confidence interval, 64.4-69.7). A total of 69.2% of INR tests conducted at home were within the TTR compared with 64.3% of INR tests conducted at a hospital or pathology service (P=0.07). One major bleeding event occurred and there was 1 thrombotic episode. PST demonstrated noninferior warfarin stability compared with routine methods. Routine outcome evaluation of pediatric anticoagulation management within single institutions is necessary to confirm the success of such programs.
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Jones et al. (2016) conducted a cohort in Pediatric patients on long-term warfarin therapy (n=164). Patient self-testing (PST) at home vs. Routine methods (hospital or pathology service) was evaluated on Time in therapeutic range (TTR) (p=0.07). Patient self-testing of INR at home demonstrated noninferior warfarin stability compared with routine methods, achieving 69.2% vs 64.3% of tests within the therapeutic range (P=0.07).
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