Key result
Melatonin administration significantly inhibited ghrelin and increased nesfatin-1 levels, whereas pinealectomy increased ghrelin and suppressed nesfatin-1 (p<0.01).
Why the study?
The study was conducted to investigate the relationship between the pineal gland and the hormones ghrelin and nesfatin-1 in rats.
Does pinealectomy and melatonin supplementation alter serum ghrelin and nesfatin-1 levels in male rats?
Does pinealectomy and melatonin supplementation alter serum ghrelin and nesfatin-1 levels in male rats?
The pineal gland and melatonin play a critical role in regulating the nutrition-related hormones ghrelin and nesfatin-1 in rats.
Melatonin-pineal effects on appetite hormones in rats are hypothesis-generating; leaves open translation to human cardiometabolic research.
Objective: In this study, it was aimed to investigate the relationship between the pineal gland and ghrelin and nesfatin-1 hormones in rats. Methods: A total of 36 male rats were used in the study, and the animals were divided into 4 groups. Group 1, Control; Group 2, Pinealectomy (Px); Group 3, Px+Melatonin; Group 4 Melatonin. After the end of the experimental applications, melatonin, ghrelin and nesfatin-1 levels (ELISA) were determined in the blood samples taken from the animals. Results: While pinealectomy resulted in suppression of melatonin levels, melatonin supplementation led to a significant increase in blood melatonin levels (p<0.01). Melatonin supplementation suppressed ghrelin levels, while pinealectomy increased ghrelin levels (P<0.01). On the other hand, Nesfatin-1 levels, which increased with melatonin support, were significantly suppressed by pinealectomy (p<0.01). Conclusion: The results of the current study show that the pineal gland may have important effects on the hormones ghrelin and nesfatin-1, which play critical roles in nutrition. In conclusion melatonin supplementation inhibites ghrelin, and but increases nesfatin-1.
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Sönmez et al. (2023) studied Healthy rats (n=36). Pinealectomy and/or Melatonin vs. Control was evaluated on Serum ghrelin and nesfatin-1 levels (p=<0.01). Melatonin administration significantly inhibited ghrelin and increased nesfatin-1 levels, whereas pinealectomy increased ghrelin and suppressed nesfatin-1 (p<0.01).
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