Key result
Carotid stiffening was associated with incident stroke independently of cardiovascular risk factors and aortic stiffness, and improved stroke risk prediction.
Why the study?
Does carotid stiffening predict incident stroke independently of traditional cardiovascular risk factors?
Meta-Analysis
Does carotid stiffening predict incident stroke independently of traditional cardiovascular risk factors?
Carotid stiffness is an independent risk factor for incident stroke and improves risk prediction beyond traditional Framingham risk factors and aortic stiffness, suggesting it as a potential target for prevention.
May refine stroke risk stratification beyond standard factors; supports further trials to test if targeting carotid stiffness improves outcomes.
Carotid stiffening is considered an important element in the pathogenesis of cerebrovascular diseases. These include stroke as well as vascular dementia and depression. However, results of individual studies evaluating the association between carotid stiffening and incident stroke have been inconsistent. Therefore, we have conducted a systematic review and meta-analysis, showing that carotid stiffening is associated with incident stroke independently of cardiovascular risk factors and aortic stiffness. In addition, carotid stiffening improved stroke risk prediction beyond the Framingham stroke risk factors and aortic stiffness. Other studies have shown that carotid stiffening is associated with a higher incidence of vascular dementia and depressive symptoms. This suggests that carotid stiffness is a potential separate target for prevention strategies of cerebrovascular disease.
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Sloten et al. (2016) conducted a meta-analysis in Cerebrovascular disease. Carotid stiffening was evaluated on Incident stroke. Carotid stiffening was associated with incident stroke independently of cardiovascular risk factors and aortic stiffness, and improved stroke risk prediction.
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