Effects of self-assembled fibers on the synthesis, characteristics and biomedical applications of CCAG hydrogels

were formed. The gelling time and swelling behaviors were dependent on the intertwining, overlap and adsorption of the polymer chains at various temperatures and pH. Furthermore, biomedical applications were evaluated by transmission electron microscopy (TEM), immunohistochemical analysis and haematoxylin and eosin (H&E) staining. The effect of the fibers on the histocompatibility of the hydrogels revealed that the fibers inside the hydrogel pores reduced the quantity of macrophages, decreased the degree of inflammation, and improved the anti-degradation of the modified hydrogels. This type of new hydrogel emerges as an interesting injectable filling biomaterial for tissue engineering.