Key result
Hemofiltration during cardiopulmonary bypass or perioperative corticosteroids did not decrease the incidence of postoperative atrial fibrillation compared to placebo (36% and 41% vs 21%; P=0.057).
Why the study?
Does hemofiltration during cardiopulmonary bypass or perioperative steroid therapy reduce the incidence of new onset atrial fibrillation in patients undergoing cardiac surgery?
Population
185 patients undergoing cardiac surgery without a history of chronic atrial fibrillation
Comparison
Hemofiltration during cardiopulmonary bypass or… vs Placebo (control group)
Design
Cohort, Patients were originally randomized to 1 of 3 groups in the primary…
Follow-up
Postoperative period
Authors
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Neither intervention supports routine use to prevent postoperative atrial fibrillation; leaves open efficacy pending randomized trials.
RCT (n=185)
double-blind
randomized to 1 of 3 groups
Does hemofiltration during cardiopulmonary bypass or perioperative steroid therapy reduce the incidence of new onset atrial fibrillation in patients undergoing cardiac surgery?
Absolute Event Rate: 36% vs 21%
p-value: p=0.057
Neither hemofiltration during cardiopulmonary bypass nor perioperative corticosteroids decreased the incidence of postoperative atrial fibrillation in patients undergoing cardiac surgery.
Mauermann et al. (2010) conducted an RCT in cardiac surgery (n=185). Hemofiltration during CPB or perioperative steroid therapy vs. placebo was evaluated on new onset atrial fibrillation (p=0.057). Hemofiltration during cardiopulmonary bypass or perioperative corticosteroids did not decrease the incidence of postoperative atrial fibrillation compared to placebo (36% and 41% vs 21%; P=0.057).
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