Increased cytotoxic T-lymphocyte-mediated cytotoxicity predominant in patients with idiopathic thrombocytopenic purpura without platelet autoantibodies

Idiopathic thrombocytopenic purpura (ITP) is a common hematologic disorder manifested by autoantibody-mediated platelet destruction. In the majority of ITP patients, autoantibodies were found to be specific to GPIIb/IIIa or GPIb/IX.[1][1] It may not only damage platelets via the reticuloendothelial