Key result
Long-term oxygen therapy for 24 hours per day showed no meaningful difference compared to 15 hours per day for hospitalization or death within 1 year.
Why the study?
Does long-term oxygen therapy for 24 hours per day improve outcomes compared to 15 hours per day in patients with severe hypoxemia at rest?
Does long-term oxygen therapy for 24 hours per day improve outcomes compared to 15 hours per day in patients with severe hypoxemia at rest?
A letter to the editor questions whether the 1-year follow-up in a recent trial of 24-hour vs 15-hour oxygen therapy was sufficient to detect a mortality benefit.
To the Editor: In a multicenter, randomized, controlled trial comparing duration of long-term oxygen therapy (24 hours vs. 15 hours) in patients who had severe hypoxemia at rest, Ekström et al. (Sept. 19 issue) 1 found no meaningful between-group difference in the primary composite outcome, defined as hospitalization or death within 1 year. The authors conclude that there is no disadvantage to treating eligible patients with only 15 hours of oxygen therapy. Because previous trials of long-term oxygen therapy required a longer duration of study before showing a mortality benefit, we wonder whether the new findings actually challenge current understanding. The . . .
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A 2024 study conducted a letter in severe hypoxemia at rest. long-term oxygen therapy vs. 15 hours per day was evaluated on hospitalization or death within 1 year. Long-term oxygen therapy for 24 hours per day showed no meaningful difference compared to 15 hours per day for hospitalization or death within 1 year.
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