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Methodological analysis highlights the utility of pragmatic trials in statin-intolerant individuals, suggesting real-world designs improve evaluation of alternative lipid-lowering therapies.
Statins have adverse effects, but it's difficult to design randomized trials of alternative therapies for statin-intolerant patients. Pragmatic clinical trials, performed in the context of usual care with broad eligibility criteria, are well suited to this purpose.
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Maningat et al. (2011) studied this question.
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