Summary Glycoprotein fraction I, from the cell surface of a nonstrain-specific line of the TA3 mammary adenocarcinoma of the strain A mouse, inhibited specifically the antihuman blood-group N agglutinin of Vicia graminea and was as active as the most highly active human blood-group NN antigen preparations. Chemical studies of the glycoprotein showed it contained 2 types of carbohydrate chains, 1 of which had a terminal β-D-galactosyl grouping. This result agrees with the findings on the human blood-group NN antigen where the immunodominant structure complementary to the V. graminea agglutinin-combining site is a β-D-galactosyl grouping. This is the first time that high blood-group N-like activity has been found in nonprimates.
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Springer et al. (1972) studied this question.