During initial bone-marrow remission, 25 children with acute lymphoblastic leukemia were given 1,200 rads to the cerebrospinal axis; 10 received an additional 1,200 rads to the liver, spleen, and kidney. CNS leukemia developed in only 1 (4%) of the 25 patients during initial bone-marrow remission, compared with 30% in a similar group not treated presymptomatically. Presymptomatic irradiation of the cerebrospinal axis appears to modify the course of the disease by delaying the onset of the first CNS episodes and decreasing their frequency.
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Kim et al. (1972) studied this question.
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