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December 15, 2008The Journal of Experimental MedicineOpen Access

RS rearrangement frequency as a marker of receptor editing in lupus and type 1 diabetes

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Key result

Systemic lupus erythematosus and type 1 diabetes are associated with low recombining sequence (RS) rearrangement levels in both mouse models and human subjects.

Population

Autoimmune mouse models of systemic lupus erythematosus and type 1 diabetes, and human subjects with SLE or…

Design

Preclinical

Authors

APAnil K. PanigrahiBaylor College of MedicineNGNoah GoodmanUniversity of PennsylvaniaRERobert A. EisenbergUniversity of North Carolina at Chapel Hill

Discussion

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Implication

Hypothesis-generating for impaired receptor editing in SLE and T1D; does not support practice change.

Study Design

Type

Observational

Structured PICO

P
Population
Autoimmune mouse models of systemic lupus erythematosus (SLE) and type 1 diabetes (T1D), and human subjects with SLE or T1D
E
Exposure
Quantitative assay for recombining sequence (RS) rearrangement
O
Outcome
Levels of antibody light chain receptor editing (RS rearrangement levels)surrogate

RS rearrangement frequency serves as a marker of receptor editing and is found to be low in both mouse models and human subjects with SLE and T1D.

Cite This Study

Panigrahi et al. (2008) conducted an observational in Systemic lupus erythematosus (SLE) and type 1 diabetes (T1D). Systemic lupus erythematosus (SLE) and type 1 diabetes (T1D) was evaluated on RS rearrangement levels. Systemic lupus erythematosus and type 1 diabetes are associated with low recombining sequence (RS) rearrangement levels in both mouse models and human subjects.

synapsesocial.com/papers/6a82fb3a3efdfb27564ccbc7https://doi.org/10.1084/jem.20082053
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